H1-receptor antagonists terfenadine and loratadine inhibit spontaneous growth of neoplastic mast cells
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چکیده
منابع مشابه
Inhibition of tryptase release from human colon mast cells by histamine receptor antagonists.
The main objective of this study was to investigate the ability of histamine receptor antagonists to modulate tryptase release from human colon mast cells induced by histamine. Enzymatically dispersed cells from human colon were challenged with histamine in the absence or presence of the histamine receptor antagonists, and the tryptase release was determined. It was found that histamine induced...
متن کاملThe Comparative Effects of Four Antihistamines on Isolated Rat Atria
It has been reported that some of H1 receptor antagonists have important effects on cardiovascular system. Terfenadine as a non-sedative H1 receptor antagonist has an arrhythmogenic activity. In this study we have shown the effects of four antihistamine drugs: terfenadine, loratadine, clemastine and diphenhydramine, on the rate and contractions of isolated rat atria. Terfenadine (1-10 µM) cause...
متن کاملNeoplastic Mast Cells
Tumors composed of mas t cells (1) have been shown to conta in hepar in in amoun t s t ha t v a r y wi th the granular content of the neoplast ic cells. This va r i a t ion in the granules finds expression in the size, number , and t inc tor ia l and opt ical proper t ies o f the cytoplasmic par t i cu la te m a t t e r (2). Cytological character is t ics of this sort can be observed in grea t ...
متن کاملEffects of chlorpheniramine and hydroxyzine administration, as histamine H1- receptor antagonists, on the nociception threshold of cholestatic rats
Introduction: The elevated endogenous opioid tone in cholestasis is associated with changes including an increase in the nociception threshold. We aimed to study the effect of chlorpheniramine and hydroxyzine, H1-receptor antagonists, on modulation of nociception in a model of elevated endogenous opioid tone, cholestasis. Methods: Cholestasis was induced by ligation of main bile duct using ...
متن کاملEffects of intracerebroventricular injection of histamine and H1, H2 receptor antagonists on electrocardiographic parameters in broiler chickens
The aim of this study was to assess the effects of exogenous histamine and H1 and H2 central receptorson electrocardiographic (ECG) parameters, heart rate and mean electrical axis in broiler chickens. For thispurpose, Ross broiler chickens (750-800 g weight) received intracerebroventricularly (ICV) histamine.Moreover, to determine the receptors involved in histamine-induced alterations in ECG c...
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ژورنال
عنوان ژورنال: Experimental Hematology
سال: 2010
ISSN: 0301-472X
DOI: 10.1016/j.exphem.2010.05.008